Safety in Combat Sports: Is Boxing Safer?

Combat sports are widely regarded as one of the most dangerous sports or activities an athlete can participate in. Leading the way in terms of popularity is the sport of boxing and Mixed Martial Arts (MMA). The resounding consensus among combat sports fans and athletes is that the sport of boxing is the safest option, but with the more recent discovery of Chronic traumatic encephalopathy (CTE) and the brain damage that occurs because of repeated strikes to the head, it appears that boxing is the most dangerous combat sport. The reason for my research project is to see what sport is in fact is the most dangerous and what makes it so detrimental to an athlete’s health. Scientific breakthroughs and testing have been developing regarding the effects of the human brain after receiving blows to the head and concussions all together. Keywords: Combat Sports, CT

A Fresh Look at Energy, Materials, and Labor in Agriculture

An understanding of agriculture's energy, material, and labor requirements is essential for achieving economic and ecological sustainability, and for assessing the effectiveness of relevant policy decisions (biofuel subsidies, regulations, labeling, etc.). Previous studies of energy, materials, and labor use in farming have been based on either unverified voluntary reporting or test plots, rather than on the high-resolution measurements of mass and energy flows. Here we present a recursive analysis of 1.25 million data points describing in unprecedented detail the resource transactions on a 60 ha farm functioning for over 6 years. This analysis highlights the importance of accounting for all types of materials, as well as capital equipment, non-field labor, and commuting. The superior energy efficiency of the farm's energy-saving methods, including green manure, crop rotation, composting, and short-duration grazing -- compared with conventional methods -- persists even when the higher labor requirements are taken into account. One of the farm's methods, however -- the use of horses for traction -- is shown to be highly inefficient compared with mechanical tractors

If historic marine pollution ceases, will the natural intertidal community return? How exposure to and release from pollution disturbance shapes rocky intertidal communities in the Salish Sea

Marine ecosystems in the Salish Sea are subject to a variety of pollution-based disturbances that restructure the composition of the vegetative and animal communities. A prime historical example of this is the effluent discharged from pulp mills across the province, which have been shown to have substantial negative impacts on coastal biodiversity. However, as environmental regulations have become more stringently enforced and the economic drivers of pulp mills have slowed down, in some areas much of this pollution has abated. The diminishment and in some cases, elimination of such disturbances provides a unique opportunity to assess the recovery of communities once affected by the mill discharge. This also allows an opportunity to better understand how to develop successful marine habitat reclamation strategies for coastal sites when pollution inputs may also be present. To develop a marine ecosystem assessment model, we used a long-term monitoring dataset spanning three decades to study rocky intertidal communities situated around Salish Sea pulp mills in Howe Sound, Powell River and compared with sites in Prince Rupert. Using this dataset, we demonstrate how proximity to the pollution source negatively influenced the intertidal community at these sites. Next, we examine how the community composition shifts and recovers once the pollution disturbance is alleviated. Lastly, we take a specific look at which species and which life history traits are best able to survive in a disturbed environment and which species are best able to recolonize those once disturbed locations. This research provides insight into classic ecological theory, applied understanding of the impacts and implications of anthropogenic activity in marine ecosystems via ecological risk assessment, and novel methods by which to assess those industrial impacts and recommend successful reclamation and restoration strategies

Boundary Shear Acceleration in the Jet of MKN501

The high resolution image of the jet of the BL Lac object MKN501 in radio, show a limb-brightened feature. An explanation of this feature as an outcome of differential Doppler boosting of jet spine and jet boundary due to transverse velocity structure of the jet requires large viewing angle. However this inference contradicts with the constraints derived from the high energy $\gamma$-ray studies unless the jets bends over a large angle immediately after the $\gamma$-ray zone (close to the central engine). In this letter we propose an alternate explanation to the limb-brightened feature of MKN501 by considering the diffusion of electrons accelerated at the boundary shear layer into the jet medium and this consideration does not require large viewing angle. Also the observed difference in the spectral index at the jet boundary and jet spine can be understood within the frame work of shear acceleration.Comment: 5 pages, accepted for publication in MNRA

Cultivated Vaginal Microbiomes Alter HIV-1 Infection and Antiretroviral Efficacy in Colonized Epithelial Multilayer Cultures

There is a pressing need for modeling of the symbiotic and at times dysbiotic relationship established between bacterial microbiomes and human mucosal surfaces. In particular clinical studies have indicated that the complex vaginal microbiome (VMB) contributes to the protection against sexually-transmitted pathogens including the life-threatening human immunodeficiency virus (HIV-1). The human microbiome project has substantially increased our understanding of the complex bacterial communities in the vagina however, as is the case for most microbiomes, very few of the community member species have been successfully cultivated in the laboratory limiting the types of studies that can be completed. A genetically controlled ex vivo model system is critically needed to study the complex interactions and associated molecular dialog. We present the first vaginal mucosal culture model that supports colonization by both healthy and dysbiotic VMB from vaginal swabs collected from routine gynecological patients. The immortalized vaginal epithelial cells used in the model and VMB cryopreservation methods provide the opportunity to reproducibly create replicates for lab-based evaluations of this important mucosal/bacterial community interface. The culture system also contains HIV-1 susceptible cells allowing us to study the impact of representative microbiomes on replication. Our results show that our culture system supports stable and reproducible colonization by VMB representing distinct community state types and that the selected representatives have significantly different effects on the replication of HIV-1. Further, we show the utility of the system to predict unwanted alterations in efficacy or bacterial community profiles following topical application of a front line antiretroviral

Water availability, root depths and 2017 crop yields

During 2016 and 2017, June-July precipitation was below normal in many parts of Iowa creating midseason concerns about potential yield loss due to water stress. However, these concerns were not realized. In contrast, 2016 and 2017 crop yields over-performed yields obtained in many years with average of above average June-July precipitation. In Iowa, deep root systems, high soil water storage capacity, and shallow water tables are common explanations for high yields in years with below normal precipitation. How deep can roots grow? How much does groundwater contribute to the yields? To answer these questions and more, the Forecast and Assessment of Cropping sysTemS (FACTS) project was established in 201

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen

Exclusive rho^0 muoproduction on transversely polarised protons and deuterons

The transverse target spin azimuthal asymmetry A_UT in hard exclusive production of rho^0 mesons was measured at COMPASS by scattering 160 GeV/c muons off transversely polarised protons and deuterons. The measured asymmetry is sensitive to the nucleon helicity-flip generalised parton distributions E^q, which are related to the orbital angular momentum of quarks in the nucleon. The Q^2, x_B and p_t^2 dependence of A_UT is presented in a wide kinematic range. Results for deuterons are obtained for the first time. The measured asymmetry is small in the whole kinematic range for both protons and deuterons, which is consistent with the theoretical interpretation that contributions from GPDs E^u and E^d approximately cancel.Comment: 20 pages, 9 figures and 4 tables, updated author lis

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization

Background & Aims Risks for some cancers increase with height. We investigated the relationship between height and risk of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE). Methods We analyzed epidemiologic and genome-wide genomic data from individuals of European ancestry in the Barrett's and Esophageal Adenocarcinoma Consortium, from 999 cases of EAC, 2061 cases of BE, and 2168 population controls. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height and risks of EAC and BE. We performed a Mendelian randomization analysis to estimate an unconfounded effect of height on EAC and BE using a genetic risk score derived from 243 genetic variants associated with height as an instrumental variable. Results Height was associated inversely with EAC (per 10-cm increase in height: OR, 0.70; 95% CI, 0.62–0.79 for men and OR, 0.57; 95% CI 0.40–0.80 for women) and BE (per 10-cm increase in height: OR, 0.69; 95% CI, 0.62–0.77 for men and OR, 0.61; 95% CI, 0.48–0.77 for women). The risk estimates were consistent across strata of age, education level, smoking, gastroesophageal reflux symptoms, body mass index, and weight. Mendelian randomization analysis yielded results quantitatively similar to those from the conventional epidemiologic analysis. Conclusions Height is associated inversely with risks of EAC and BE. Results from the Mendelian randomization study showed that the inverse association observed did not result from confounding factors. Mechanistic studies of the effect of height on EAC and BE are warranted; height could have utility in clinical risk stratification